Best Luxury Hotels in St Louis

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Why Choose a Staycation in St Louis

St. Louis offers an enticing array of luxury hotels, perfect for an indulgent staycation in the heart of the city. Whether you’re drawn to the grandeur of historic landmarks, the energy of downtown, or the city’s renowned culinary and arts scenes, these sophisticated retreats provide a seamless blend of comfort and style. Enjoy world-class amenities and attentive service while rediscovering St. Louis from a fresh perspective—all with the ease and assurance of booking your next getaway close to home.

Best Areas for Luxury Hotels in St Louis

These St Louis neighborhoods—Downtown, Central West End, and Clayton—feature luxury hotels with sophisticated amenities, acclaimed dining, and easy access to the city’s top cultural attractions for an indulgent urban staycation.

01

Downtown

Downtown St. Louis offers a sophisticated urban retreat with luxury hotels steps from the iconic Gateway Arch, acclaimed fine dining, and vibrant arts and entertainment venues.

Four Seasons Hotel St. Louis

Arch views from the spa deck

The Four Seasons faces the Gateway Arch from Laclede's Landing with an eighth-floor pool deck, Cinder House's Brazilian-rooted kitchen, and the city's most polished service.

21c Museum Hotel St. Louis

Art museum you sleep in

21c filled the 1926 YMCA downtown with free contemporary-art galleries, Idol Wolf's Spanish plates, and locust-green penguins — downtown's most interesting overnight.

02

Central West End

Stay in the heart of the Central West End, where elegant hotels place you steps from chic boutiques, acclaimed restaurants, and the lush beauty of Forest Park.

The Chase Park Plaza Royal Sonesta

The Central West End icon

The 1922 Chase Park Plaza remains St. Louis glamour — a five-screen cinema, pool deck, and the Preston's cocktails — at the Central West End's mansion-lined edge of Forest Park.

03

Forest Park

Indulge in world-class spa treatments and gourmet dining at luxury hotels just steps from Forest Park’s renowned art museums, lush gardens, and scenic walking trails.

The Cheshire

Tudor inn at Forest Park's corner

The Cheshire's half-timbered Tudor revival — literary-themed rooms, Fox & Hounds tavern fireplaces — sits at Forest Park's southwest gate, minutes from the zoo and art museum.

04

The Delmar Loop

Enjoy effortless access to The Delmar Loop’s trendy boutiques and acclaimed eateries, all just moments from your plush suite at one of St. Louis’s premier luxury hotels.

Moonrise Hotel

Space-age Delmar Loop landmark

Under the world's largest man-made rotating moon, the Moonrise runs cosmic-kitsch rooms and a rooftop terrace over the Delmar Loop's music venues and neon — Chuck Berry's statue outside.

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